2025, Vol. 6, Issue 2, Part A
Neuroprotective role of Vitamin C against lead- induced impairments in negative geotaxis of Drosophila melanogaster
Author(s): Shravani MNR, S Priyanka Rani, Sinchana M, Tanuja N, Sindhu K and Shakunthala V
Abstract: Lead is a toxic environmental pollutant known to impair the nervous system. This study evaluates the effect of chronic lead exposure on climbing behaviour in Drosophila melanogaster and the neuroprotective potential of Vitamin C. Adult flies were exposed to different lead concentrations (0, 80, 120, and 170 ppm) with or without Vitamin C supplementation. Locomotor performance was assessed using the negative geotaxis assay across 30 days at 10-day intervals, with six replicates per group. Climbing success decreased significantly (p < 0.001) in the 120ppm lead group. Partial recovery was observed in the 170 ppm + Vitamin C group, indicating a protective effect. Sex-based differences were noted, with males showing greater susceptibility. These results highlight the potential of Vitamin C in mitigating lead-induced neurotoxicity and validate Drosophila as a model for behavioural assays in toxicological studies.
DOI: 10.33545/27080013.2025.v6.i2a.228
Pages: 22-26 | Views: 424 | Downloads: 124
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How to cite this article:
Shravani MNR, S Priyanka Rani, Sinchana M, Tanuja N, Sindhu K, Shakunthala V. Neuroprotective role of Vitamin C against lead- induced impairments in negative geotaxis of Drosophila melanogaster. Acta Entomol Zool 2025;6(2):22-26. DOI: 10.33545/27080013.2025.v6.i2a.228
