2025, Vol. 6, Issue 2, Part A
Lead acetate induced neurotoxicity in Drosophila melanogaster Larvae: Protective role of Vitamin C in a crawling assay
Author(s): S Priyanka Rani, Sinchana M, Tanuja N, Shravani MNR, Sindhu K and Shakunthala V
Abstract: Heavy metal contamination, especially from lead acetate, presents serious ecological and biological hazards due to its ability to accumulate in organisms and cause toxicity. This study evaluated the impact of lead acetate on the locomotor activity of Drosophila melanogaster larvae and examined the protective role of vitamin C. Larvae were exposed to different concentrations of lead acetate, both with and without vitamin C supplementation, and their crawling behaviour was assessed using a grid-based locomotor assay. A significant, concentration-dependent reduction in movement was observed in larvae exposed to lead acetate, indicating its neurotoxic effects. Supplementation with vitamin C showed partial recovery in locomotor activity, suggesting a protective effect. The results point toward the effectiveness of Drosophila melanogaster as a practical model for evaluating neurotoxic effects and exploring the benefits of natural antioxidants like Vitamin C.
DOI: 10.33545/27080013.2025.v6.i2a.227
Pages: 18-21 | Views: 726 | Downloads: 242
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How to cite this article:
S Priyanka Rani, Sinchana M, Tanuja N, Shravani MNR, Sindhu K, Shakunthala V. Lead acetate induced neurotoxicity in Drosophila melanogaster Larvae: Protective role of Vitamin C in a crawling assay. Acta Entomol Zool 2025;6(2):18-21. DOI: 10.33545/27080013.2025.v6.i2a.227
